Alaine Aminotransferase (ALT)
Its’ Uses:
ALT is used to identify hepatocellular diseases of teh liver. It is also an acurate monitor of improvement or worsening of these diseases.
Interfering factors:
Drugs that may increase ALT levels include: acetaminophen, allopurinol, aminosalic acid, ampicillin, azathioprine, carbamazepine, cephalosporins, chorliazepoxide, isoniazid, methotrexate, methyldopa, nafcillin, nalidix acid, nitrofurantoin, oral contraceptives, oxacillin, phenothiazines, phenylbutazone, phenytoin, procainamide, propoxyphene, propranol, quinidine, salicylates.
Diagnostic Significance:
Significantly increased levels:
- • Hepatitis
- • Hepatic necrosis
- • Hepatic ischemia
Moderatly increased levels:
- • Cirrhosis
- • Cholestasis
- • Hepatic tumor
- • Hepatotoxic drugs
- • Obstructive jaundice
- • Severe burns
- • Trauma to striated muscle
Mildly increased levels:
- • Myositis
- • Pancreatitis
- • Myocardial infarction
- • Infectious mononucleosis
- • Shock
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The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.